How reach Tremiti Islands...

By car
Motorway A14 to the Termoli-Molise exit; boarding at the port of Termoli, with hydrofoil and ship service every day from morning to afternoon. 

NOTE: The car can; be left at the guarded parking lot of the ports of departure.
On the islands it is not allowed to bring your own car.

By train
Train from the city; starting until Termoli (all the main trains stop); from the train station a public shuttle service will take you to the port for boarding. 

If you decide to arrive in Foggia, there is a daily helicopter service to the island of San Domino.